Department of Biomedical Engineering, College of Health Science, Yonsei University, 234 Maeji-ri, Heungup-myun, Wonju, Gangwon-do, 220-710, Republic of Korea.
Neurosci Lett. 2013 Aug 26;548:120-5. doi: 10.1016/j.neulet.2013.05.079. Epub 2013 Jun 12.
Mismatch negativity (MMN) is a negative component of event-related potential (ERP) that reflects auditory deviant detection. Previous studies repeatedly suggested that MMN is generated by the fronto-temporal network. However, it is still unclear how the frontal and temporal areas interact. To verify this, we observed the spatiotemporal pattern of inter-regional functional connectivity using phase synchrony and Granger causality, by analyzing event-related electroencephalograms (EEGs) elicited by standard and deviant tones in an oddball paradigm. Strong theta-band phase synchrony and bidirectional Granger causality were observed between the frontal and temporal areas during the processing of auditory deviants, especially at the temporal interval of MMN. Our results support the hypothesis that fronto-temporal interactions are crucial to the generation of MMN during auditory deviant processing.
失匹配负波（MMN）是事件相关电位（ERP）的一个负成分，反映了听觉偏差检测。先前的研究反复表明，MMN 是由额颞网络产生的。然而，目前尚不清楚额区和颞区如何相互作用。为了验证这一点，我们使用相位同步和格兰杰因果关系，通过分析在Oddball 范式中标准音和偏差音诱发的事件相关脑电图（EEG），观察了额颞区之间的区域间功能连接的时空模式。在听觉偏差处理过程中，尤其是在 MMN 的时间间隔内，观察到额区和颞区之间存在较强的θ波段相位同步和双向格兰杰因果关系。我们的结果支持这样的假设，即额颞相互作用对于听觉偏差处理过程中 MMN 的产生至关重要。
