MacLean Shannon E, Ward Lawrence M
Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Brain Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Clin Neurophysiol. 2014 Aug;125(8):1604-17. doi: 10.1016/j.clinph.2013.12.109. Epub 2014 Jan 11.
We performed an experiment designed to reveal the brain-regional network dynamics underlying both automatic and intentional auditory change detection as typically indexed by the mismatch negativity (MMN) event-related potential (ERP).
High-density EEG was recorded while participants heard a stream of standard pure tones, into which occasional (14%) frequency deviants were inserted. In a first run they listened passively while watching a closed-captioned movie, whereas in a second run they pressed a button each time they detected a deviant while watching the movie with neither sound nor captioning.
Independent component analysis revealed independent components that we localized to temporal and frontal regional brain sources relevant to the generation of the MMN. Relative power in various oscillatory frequency bands, computed from a wavelet analysis on the time series of these independent components, was modulated by task demands and stimulus type, as was dynamic phase-locking between pairs of the independent components in those same frequency bands.
These results support a hierarchical model of MMN generation that emphasizes information processing and transfer between temporal and frontal brain regions.
In addition to enhancing the use of the MMN to evaluate some aspects of central auditory functioning, these results could be important for the evaluation of alterations in other cognitive functions or in consciousness.
我们进行了一项实验，旨在揭示由失配负波（MMN）事件相关电位（ERP）典型表征的自动和有意听觉变化检测背后的脑区网络动态。
在参与者聆听一连串标准纯音时记录高密度脑电图，其中偶尔（14%）插入频率偏差音。在第一次测试中，他们边观看带字幕的电影边被动聆听，而在第二次测试中，他们在观看既无声音也无字幕的电影时，每次检测到偏差音就按下按钮。
独立成分分析揭示了我们定位到与MMN产生相关的颞叶和额叶脑区来源的独立成分。从这些独立成分的时间序列小波分析计算得出的各种振荡频段的相对功率，受到任务需求和刺激类型的调制，这些相同频段中独立成分对之间的动态锁相也是如此。
这些结果支持MMN产生的层次模型，该模型强调颞叶和额叶脑区之间的信息处理和传递。
除了加强使用MMN来评估中枢听觉功能的某些方面外，这些结果对于评估其他认知功能或意识的改变可能很重要。
