Steger R M, Ramos R L, Cao R, Yang Q, Chen C-C, Dominici J, Brumberg J C
Neuropsychology Doctoral Subprogram, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
Department of Psychology, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA; Department of Biomedical Science, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Neuroscience. 2013 Sep 17;248:165-79. doi: 10.1016/j.neuroscience.2013.06.004. Epub 2013 Jun 14.
An increasing number of studies indicate that there exists greater diversity of cortical neurons than previously appreciated. In the present report, we use a combination of physiological and morphological methods to characterize cortical neurons in infragranular layers with apical dendrites pointing toward the white-matter compared to those neurons with apical dendrites pointing toward the pia in both mouse and rat neocortex. Several features of the dendritic morphology and intrinsic and synaptic physiology of these "inverted" neurons revealed numerous differences among this cell type between species. We also found differences between the different cell types within the same species. These data reveal that similar cell types in the rat and mouse may not always share similar physiological and morphological properties. These data are relevant to models of information processing through micro- and larger neocortical circuits and indicate that different cell types found within similar lamina can have different functional properties.
越来越多的研究表明，皮层神经元的多样性比之前所认识到的要大。在本报告中，我们运用生理学和形态学方法相结合，对小鼠和大鼠新皮层中，相较于顶树突指向软脑膜的神经元，顶树突指向白质的颗粒下层皮层神经元进行特征描述。这些“倒置”神经元的树突形态、内在及突触生理学的若干特征揭示了不同物种间该细胞类型存在诸多差异。我们还发现同一物种内不同细胞类型之间也存在差异。这些数据表明，大鼠和小鼠中相似的细胞类型并不总是具有相似的生理和形态特性。这些数据与通过微尺度和更大尺度新皮层回路进行信息处理的模型相关，并表明在相似层中发现的不同细胞类型可能具有不同的功能特性。
