Morohashi Yuichi, Tomita Taisuke
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Biochim Biophys Acta. 2013 Dec;1828(12):2855-61. doi: 10.1016/j.bbamem.2013.06.001. Epub 2013 Jun 11.
Intramembrane-cleaving proteases (I-CLiPs) are membrane embedded proteolytic enzymes. All substrates identified so far are also membrane proteins, involving a number of critical cellular signaling as well as human diseases. After synthesis and assembly at the endoplasmic reticulum, membrane proteins are exported to the Golgi apparatus and transported to their sites of action. A number of studies have revealed the importance of the intracellular membrane trafficking in i-CLiP-mediated intramembrane proteolysis, not only for limiting the unnecessary encounter between i-CLiPs and their substrate but also for their cleavage site preference. In this review, we will discuss recent advances in our understanding of how each i-CLiP proteolysis is regulated by intracellular vesicle trafficking. This article is part of a Special Issue entitled: Intramembrane Proteases.
膜内裂解蛋白酶（I-CLiPs）是嵌入膜中的蛋白水解酶。目前已鉴定出的所有底物也都是膜蛋白，涉及许多关键的细胞信号传导以及人类疾病。膜蛋白在内质网合成和组装后，被转运至高尔基体并输送到其作用位点。大量研究表明，细胞内膜运输在I-CLiP介导的膜内蛋白水解过程中起着重要作用，这不仅体现在限制I-CLiP与其底物之间不必要的相遇，还体现在对其裂解位点偏好性的影响上。在这篇综述中，我们将讨论在理解每种I-CLiP蛋白水解如何受细胞内囊泡运输调控方面的最新进展。本文是名为《膜内蛋白酶》的特刊的一部分。
