膜内蛋白水解调控在病毒感染和抗病毒免疫中的作用。
Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.
作者信息
Ye Jin
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9046, USA.
出版信息
Biochim Biophys Acta. 2013 Dec;1828(12):2926-32. doi: 10.1016/j.bbamem.2013.05.005.
Abstract
Regulated intramembrane proteolysis (RIP) is a signaling mechanism through which transmembrane precursor proteins are cleaved to liberate their cytoplasmic and/or luminal/extracellular fragments from membranes so that these fragments are able to function at a new location. Recent studies have indicated that this proteolytic reaction plays an important role in host-virus interaction. On one hand, RIP transfers the signal from the endoplasmic reticulum (ER) to nucleus to activate antiviral genes in response to alteration of the ER caused by viral infection. On the other hand, RIP can be hijacked by virus to process transmembrane viral protein precursors and to destroy transmembrane antiviral proteins. Understanding this Yin and Yang side of RIP may lead to new strategies to combat viral infection. This article is part of a Special Issue entitled: Intramembrane Proteases.
摘要
调节性膜内蛋白水解（RIP）是一种信号传导机制，通过该机制，跨膜前体蛋白被切割，从而从膜上释放出其胞质和/或腔/细胞外片段，使这些片段能够在新的位置发挥作用。最近的研究表明，这种蛋白水解反应在宿主-病毒相互作用中起着重要作用。一方面，RIP将信号从内质网（ER）传递到细胞核，以响应病毒感染引起的内质网变化来激活抗病毒基因。另一方面，RIP可能被病毒劫持，用于处理跨膜病毒蛋白前体并破坏跨膜抗病毒蛋白。了解RIP的阴阳两面可能会带来对抗病毒感染的新策略。本文是名为：膜内蛋白酶的特刊的一部分。
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