Messick Craig A, Londono Jorge Mario Rosselli, Hull Tracy
Pol Przegl Chir. 2013 May;85(5):253-61. doi: 10.2478/pjs-2013-0039.
Presacral tumors are rare with few published studies in the literature. It is unknown whether the course of the disease and the required treatment differs between pediatric and adult patients. The aim of the study was to compare presenting symptoms, surgical treatment, pathology, and recurrence rates of presacral tumors in these two groups.
An IRB-approved chart review was conducted for patients diagnosed with a presacral tumor at the Cleveland Clinic between 1981 and 2011. Symptoms, physical exam, surgical details, tumor histology, and outcomes were collected as part of the review. Patients were divided into two groups: pediatric (< 18 years n=14) and adult (≥ 18 years n=50).
The most common symptom was a mass in pediatric and pain in adult patients. The most common pediatric primary tumor was a teratoma (n=5, 36%) versus Hamartoma/tailgut cyst (n=17, 34%) in adult patients. Three pediatric and nine adult patients developed tumor recurrences, and 2/14 (14%) pediatric and 4/50 (8%) adult patients developed metastases.
This study summarizes the presentation, evaluation and management of pediatric and adult presacral tumors at tertiary referral center. The presentation, histology, and management of presacral tumors vary depending upon whether they occur in pediatric or adult patients and recognition of potential differences may influence management.
骶前肿瘤罕见，文献中发表的研究较少。目前尚不清楚儿童患者和成年患者的疾病进程及所需治疗是否存在差异。本研究的目的是比较这两组骶前肿瘤的临床表现、手术治疗、病理及复发率。
对1981年至2011年间在克利夫兰诊所被诊断为骶前肿瘤的患者进行了经机构审查委员会批准的病历回顾。作为回顾的一部分，收集了症状、体格检查、手术细节、肿瘤组织学及预后情况。患者分为两组：儿童组（<18岁，n = 14）和成年组（≥18岁，n = 50）。
儿童患者最常见的症状是肿块，成年患者是疼痛。儿童最常见的原发性肿瘤是畸胎瘤（n = 5，36%），而成年患者是错构瘤/尾肠囊肿（n = 17，34%）。3名儿童患者和9名成年患者出现肿瘤复发，2/14（14%）的儿童患者和4/50（8%）的成年患者发生转移。
本研究总结了三级转诊中心儿童和成年骶前肿瘤的表现、评估及管理。骶前肿瘤的表现、组织学及管理因患者是儿童还是成年而异，认识到潜在差异可能会影响治疗管理。
