Nursalim Alvin, Siregar Parlindungan, Widyahening Indah S
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Acta Med Indones. 2013 Apr;45(2):150-6.
to determine whether the administration of folic acid, vitamin B6 and vitamin B12 would lead to reduction of cardiovascular complication and mortality among CKD patients.
a search was conducted on PubMed and Google. The selection of title and abstract was conducted using inclusion and exclusion criterias, which led to six relevant articles. The selected studies were critically appraised for its validity, importance and applicability.
the administration of folic acid and vitamin B reduce homocysteine level among CKD patients. Despite homocysteine level reduction, all six studies reported similar findings that folic acid and vitamin B supplementation did not significantly reduce cardiovascular complication and mortality.
treatment with folic acid, vitamin B6 and vitamin B12 did not reduce cardiovascular complication and mortality among CKD patients.
确定给予叶酸、维生素B6和维生素B12是否会降低慢性肾脏病（CKD）患者心血管并发症的发生率及死亡率。
在PubMed和谷歌上进行检索。根据纳入和排除标准筛选标题和摘要，最终得到6篇相关文章。对所选研究的有效性、重要性和适用性进行严格评估。
给予叶酸和维生素B可降低CKD患者的同型半胱氨酸水平。尽管同型半胱氨酸水平有所降低，但所有6项研究均报告了相似的结果，即补充叶酸和维生素B并不能显著降低心血管并发症的发生率及死亡率。
叶酸、维生素B6和维生素B12治疗不能降低CKD患者心血管并发症的发生率及死亡率。
