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拟南芥 FLC 类成员形成开花抑制复合物，协调对内源和环境线索的反应。

Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues.

机构信息

Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.

出版信息

Nat Commun. 2013;4:1947. doi: 10.1038/ncomms2947.

DOI:10.1038/ncomms2947
PMID:23770815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3709509/
Abstract

The developmental transition to flowering is timed by endogenous and environmental signals through multiple genetic pathways. In Arabidopsis, the MADS-domain protein FLOWERING LOCUS C is a potent flowering repressor. Here, we report that the FLOWERING LOCUS C clade member MADS AFFECTING FLOWERING3 acts redundantly with another clade member to directly repress expression of the florigen FLOWERING LOCUS T and inhibit flowering. FLOWERING LOCUS C clade members act in partial redundancy in floral repression and mediate flowering responses to temperature, in addition to their participation in the flowering-time regulation by vernalization and photoperiod. We show that FLOWERING LOCUS C, MADS AFFECTING FLOWERING3 and three other clade members can directly interact with each other and form nuclear complexes, and that FLOWERING LOCUS C-dependent floral repression requires other clade members. Our results collectively suggest that the FLOWERING LOCUS C clade members act as part of several MADS-domain complexes with partial redundancy, which integrate responses to endogenous and environmental cues to control flowering.

摘要

成花发育的时间由内源性和环境信号通过多个遗传途径来调控。在拟南芥中，MADS 结构域蛋白 FLOWERING LOCUS C 是一个强有力的成花抑制子。在这里，我们报告称，MADS 结构域蛋白 FLOWERING LOCUS C 家族成员 MADS AFFECTING FLOWERING3 与另一个家族成员协同作用，直接抑制成花素 FLOWERING LOCUS T 的表达并抑制开花。FLOWERING LOCUS C 家族成员在花抑制中部分冗余，并介导开花对温度的响应，除了它们参与春化和光周期的开花时间调控。我们表明，FLOWERING LOCUS C、MADS AFFECTING FLOWERING3 和其他三个家族成员可以直接相互作用并形成核复合物，并且 FLOWERING LOCUS C 依赖性的花抑制需要其他家族成员。我们的结果表明，FLOWERING LOCUS C 家族成员作为几个 MADS 结构域复合物的一部分发挥作用，这些复合物具有部分冗余性，整合对内源性和环境信号的响应来控制开花。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/dd24a50caad0/ncomms2947-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/a29c5eba45f2/ncomms2947-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/4a17d5af556b/ncomms2947-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/68b5fff8c7f4/ncomms2947-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/660a6d0c98b3/ncomms2947-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/57671ef3a858/ncomms2947-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/b257f7d63147/ncomms2947-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/dd24a50caad0/ncomms2947-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/a29c5eba45f2/ncomms2947-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/4a17d5af556b/ncomms2947-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/68b5fff8c7f4/ncomms2947-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/660a6d0c98b3/ncomms2947-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/57671ef3a858/ncomms2947-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/b257f7d63147/ncomms2947-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6578/3709509/dd24a50caad0/ncomms2947-f7.jpg

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