Cherepakhina I Ia, Kozlovskiĭ V N, Efanova E A, Novokhatskiĭ A S, Alekseeva L P, Sukhar' V V, Prozorova L A, Larionova L V, Sorokin V M, Lysova L K
Mikrobiol Zh (1978). 1990 Mar-Apr;52(2):89-93.
The use of different schemes of albino mice immunization either by living or by killed preparations of the vaccine strain of Francisella tularensis when obtaining monoclonal antibodies to the tularemia microbe made it possible to reveal definite regularities in the dynamics of antibody formation. The highest titres of antibodies in sera of animals-donors of splenocytes were obtained during the daily (for 3 days) intraperitoneal immunization of mice with living vaccine or with its thrice administration to the spleen thrice with the interval of 10 days. Revaccination against a background of high titres of antibodies decreased their quantity in blood serum of mice, while that against a background of low titres increased them.
在用土拉热弗朗西斯菌疫苗株的活体制剂或死体制剂对白化小鼠进行免疫以获得针对土拉热病菌的单克隆抗体时，采用不同的免疫方案，从而有可能揭示抗体形成动态中的某些规律。在用活疫苗对小鼠进行每日（连续3天）腹腔免疫或对脾脏进行3次间隔10天的注射时，脾细胞供体动物血清中的抗体滴度最高。在高抗体滴度背景下再次接种会降低小鼠血清中的抗体量，而在低抗体滴度背景下再次接种则会增加抗体量。
