Borzenkov V M, Pomerantsev A P, Ashmarin I P
Biull Eksp Biol Med. 1993 Aug;116(8):151-3.
It has been shown, that vaccine strain of tularemia microbe, F.T.ISE., which produced recombinant beta-endorphin, when administered to CBA mice. It was shown to increase in the threshold level of pain sensitivity and is associated with peptides associated changes the stereotypic behavior. The observed correlated in time with the pattern of the dynamics of culture in the experimental animals and were associated with the level of recombinant beta-endorphin synthesis.
已经表明，当将产生重组β-内啡肽的土拉菌病微生物的疫苗株F.T.ISE.接种给CBA小鼠时，可提高疼痛敏感性的阈值水平，并且与肽相关的刻板行为变化有关。观察到的结果在时间上与实验动物体内培养物的动态模式相关，并且与重组β-内啡肽的合成水平有关。
