*Department of Ophthalmology, University Hospital of Heraklion, University of Crete, Crete, Greece; and †OKEBE, Ophthalmology Center of Northern Greece, Thessaloniki, Greece.
Cornea. 2013 Nov;32(11):1499-501. doi: 10.1097/ICO.0b013e318295e6b9.
To report 2 cases of superior limbic keratoconjunctivitis (SLK) treated with topical tacrolimus 0.03% ointment (Protopic; Fujisawa Healthcare).
A female patient aged 52 years and a male patient aged 21 years presented with SLK in both eyes. Both patients had previously received several treatments [such as topical steroids and lubrication, contact lenses, silicone punctal plugs, and vitamin A eye drops], with no improvement. Because of poor response to initial management, the authors started treatment with topical tacrolimus 0.03% twice a day. Objective tarsal conjunctiva inflammation, bulbar conjunctiva findings (such as hyperemia and thickening), cornea staining, and subjective symptoms were evaluated.
A week later, both patients were symptomatically better. Four weeks after treatment initiation, the signs of thickened and hyperemic superior conjunctiva, papillary reaction, and punctate keratopathy were almost resolved. Tacrolimus was successfully tapered in both the patients. There were no side effects.
Topical tacrolimus 0.03% ointment may be considered an additional treatment option for SLK.
报告 2 例采用他克莫司 0.03%软膏（普特彼；藤泽制药）治疗的上睑缘角结膜炎（SLK）。
一名 52 岁女性和一名 21 岁男性患者双眼均患有 SLK。两名患者均曾接受过多种治疗（如局部皮质类固醇和润滑、隐形眼镜、硅胶泪点塞和维生素 A 滴眼剂），但无改善。由于初始治疗反应不佳，作者开始采用他克莫司 0.03%，每天 2 次滴眼治疗。评估了眼脸结膜的客观炎症、球结膜表现（如充血和增厚）、角膜染色和主观症状。
一周后，两名患者的症状均有改善。治疗开始后 4 周，结膜上增厚和充血、乳头反应和点状角膜病变的体征几乎已消退。在两名患者中均成功地减少了他克莫司的剂量。无副作用。
他克莫司 0.03%软膏可被视为治疗 SLK 的一种额外治疗选择。
