Khosla Divya, Yadav Budhi Singh, Kumar Ritesh, Ghoshal Sushmita, Vaiphei Kim, Verma Roshan, Sharma Suresh C
Department of Radiotherapy and Oncology, Regional Cancer Centre, Chandigarh, India.
J Cancer Res Ther. 2013 Apr-Jun;9(2):284-6. doi: 10.4103/0973-1482.113387.
Mesenchymal neoplasms of the larynx are rare and make up approximately 0.3% to 1.0% of all malignancies at this location. Low grade myofibroblastic sarcoma (LGMS) of larynx is a rare entity. We describe a rare case of LGMS of larynx who presented with complaint of hoarseness of voice. The patient was treated with total laryngectomy plus partial pharyngectomy followed by post-operative radiotherapy. Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. The patient is alive and disease free 14 months after surgery. The characteristic clinical, histopathological features and treatment of this case are described with a literature review.
喉间叶性肿瘤较为罕见，约占该部位所有恶性肿瘤的0.3%至1.0%。喉低度恶性肌成纤维细胞肉瘤（LGMS）是一种罕见的疾病。我们描述了一例罕见的喉LGMS病例，该患者以声音嘶哑为主要症状。患者接受了全喉切除术加部分咽切除术，术后进行放疗。组织病理学检查显示，病变由梭形细胞组成，这些细胞表现出不同程度的细胞间变，并表达平滑肌肌动蛋白（SMA），局部表达S-100。手术切缘之一受累，因此患者接受了术后放疗。患者术后14个月存活且无疾病。本文结合文献复习描述了该病例的特征性临床、组织病理学特征及治疗情况。
