Shirakusa T, Ueda H, Saito T
Second Department of Surgery, School of Medicine, Fukuoka University, Japan.
Nihon Geka Gakkai Zasshi. 1990 Apr;91(4):524-8.
Twelve dogs were used for the experiment of allograft of the trachea. Under general anesthesia, the cervical trachea in the donor was exposed and five or six segments of cartilage were excised, and then, these grafts were transplanted at the central portion of the cervical trachea in the recipient. For the effective vascularization, the omental pedicle was transplanted around the graft. The immunosuppressant was administered in 5 dogs. In the experimental results, 5 dogs were survived over 30 days and one dog is now alive over 9 months with good condition. Postoperative bronchofiberscopic observation demonstrated that the formation of granulation occurred one week after transplantation and the stenosis developed and exacerbated by infection. In the long survived dog the anastomotic stenosis disappeared and the color of the mucosa of the graft was same as the recipient's. It was considered that the blood supply at the anastomotic portion was the most important factor for the viability of allograft of the trachea.
十二只狗用于气管同种异体移植实验。在全身麻醉下，暴露供体的颈部气管，切除五到六段软骨，然后将这些移植物移植到受体颈部气管的中央部分。为实现有效的血管化，将网膜蒂移植到移植物周围。五只狗使用了免疫抑制剂。实验结果显示，五只狗存活超过30天，一只狗目前存活超过9个月，状况良好。术后支气管纤维镜观察表明，移植后一周出现肉芽形成，狭窄因感染而发展和加重。在长期存活的狗中，吻合口狭窄消失，移植物黏膜颜色与受体相同。认为吻合部位的血供是气管同种异体移植存活的最重要因素。
