Takachi T, Shirakusa T, Shiraishi T, Okabayashi K, Inutsuka K, Kawahara K, Nakanishi R
Second Department of Surgery, School of Medicine, Fukuoka University, Japan.
J Thorac Cardiovasc Surg. 1995 Sep;110(3):762-7. doi: 10.1016/S0022-5223(95)70109-5.
Grafting is required when a primary reconstruction of a carinal defect is not feasible. A series of experiments in 21 dogs was conducted to assess the possibility of carinal reconstruction with the use of carinal autografts and allografts, with or without omentopexy. Carinal autograft transplantations were done without omentopexy in group A (n = 6) and with omentopexy in group B (n = 6). In group C (n = 9), carinal allograft transplantations were done with omentopexy and FK 506 was administered after operation. Survival of grafts was seen in 50% of group A, 83% of group B, and 44% of group C dogs. Postoperative bronchoscopy revealed inflammatory changes in the surviving grafts; the changes resolved more rapidly in the dogs with omentopexy than in the dogs without omentopexy. These experiments suggest that omentopexy is an effective method of facilitating survival and healing in carinal grafts and that carinal reconstruction with carinal allografts with FK 506 is feasible.
当气管隆突缺损的一期重建不可行时，就需要进行移植。我们对21只犬进行了一系列实验，以评估使用气管隆突自体移植物和同种异体移植物进行气管隆突重建的可能性，同时评估是否进行网膜固定术。A组（n = 6）在不进行网膜固定术的情况下进行气管隆突自体移植，B组（n = 6）在进行网膜固定术的情况下进行气管隆突自体移植。C组（n = 9）在进行网膜固定术的情况下进行气管隆突同种异体移植，并在术后给予FK 506。A组50%的犬、B组83%的犬和C组44%的犬出现移植物存活。术后支气管镜检查显示存活移植物有炎症改变；与未进行网膜固定术的犬相比，进行网膜固定术的犬的这些改变消退得更快。这些实验表明，网膜固定术是促进气管隆突移植物存活和愈合的有效方法，并且使用FK 506进行气管隆突同种异体移植重建气管隆突是可行的。
