Kim Ki-Tae, Tanguay Robert L
Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR ; Safer Nanomaterials Nanomanufacturing Initiative, Oregon Nanoscience and Microtechnologies Institute, Eugene, OR, USA.
Green Chem. 2013 Apr 1;15(4):872-880. doi: 10.1039/C3GC36806H.
The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of "Green Chemistry". In this review, we focus on the burgeoning diversity of new engineered nanomaterials (ENMs) and the prescient need for a nanotoxicology paradigm that quickly identifies potentially hazardous nanochemistries. Advances in predictive toxicological modeling in the developing zebrafish offer the most immediate translation to human hazard that is practically achievable with high throughput approaches. Translation in a vertebrate model that is also a low cost alternative to rodents for hazard prediction has been a desirable but elusive testing paradigm. The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. Early pipeline detection of human and environmental health impacts will quickly inform decisions in the design and production of safer commercial ENMs.
在过去十年中，设计、制造和应用更安全的产品及制造工艺一直是重要目标，并且在“绿色化学”的框架下，未来还将取得进展。在本综述中，我们关注新型工程纳米材料（ENM）迅速增长的多样性，以及对能快速识别潜在有害纳米化学性质的纳米毒理学范式的迫切需求。发育中的斑马鱼在预测毒理学建模方面的进展为人类危害提供了最直接的转化，这在高通量方法中实际上是可以实现的。在脊椎动物模型中进行转化，该模型也是用于危害预测的比啮齿动物成本更低的替代方案，一直是一种理想但难以实现的测试范式。如果在ENM发现流程的早期应用斑马鱼，其效用可以极大地促进朝着更绿色、更高效的纳米科学方向所做的努力。在流程早期检测对人类和环境健康的影响将迅速为更安全的商业ENM的设计和生产决策提供信息。
