无金属脱羧三组分偶联反应合成炔丙胺。
Metal-free decarboxylative three-component coupling reaction for the synthesis of propargylamines.
机构信息
Department of Chemistry, Chonnam National University, Gwangju, 500-757, Republic of Korea.
出版信息
Org Lett. 2013 Jul 5;15(13):3322-5. doi: 10.1021/ol401358t. Epub 2013 Jun 17.
PMID:23772690
Abstract
A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in CH3CN at 65 °C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.
摘要
发展了一种无需金属的脱羧三组分偶联反应。当炔基羧酸、多聚甲醛和胺在 CH3CN 中于 65°C 反应 3 小时时，可得到所需的炔丙胺，产率良好。该偶联反应在水溶剂中也表现出良好的收率。与末端炔烃相比，该反应对炔基羧酸具有更高的选择性。
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