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通过碱促进的顺序多组分组装简洁合成硫代甲基苯并咪唑。

Concise synthesis of -thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly.

作者信息

Tian Jingxin, Yuan Shanshan, Xiao Fuhong, Huang Huawen, Deng Guo-Jun

机构信息

Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University Xiangtan 411105 China

出版信息

RSC Adv. 2019 Sep 26;9(52):30570-30574. doi: 10.1039/c9ra06144d. eCollection 2019 Sep 23.

DOI:10.1039/c9ra06144d
PMID:35530231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072308/
Abstract

An efficient method for the synthesis of -thiomethyl benzimidazoles from -phenylenediamines, thiophenols, and aldehydes C-N/C-S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source.

摘要

描述了一种在无金属条件下由对苯二胺、硫酚和醛合成β-硫甲基苯并咪唑的有效方法，该方法涉及C-N/C-S键的形成。在该反应体系中，底物上连接的多种官能团都能很好地耐受。使用稳定且低毒的多聚甲醛作为碳源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0910162a91b2/c9ra06144d-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/e2cebac73a57/c9ra06144d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0095c2c34f2c/c9ra06144d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0435d1bb286d/c9ra06144d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0910162a91b2/c9ra06144d-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/e2cebac73a57/c9ra06144d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0095c2c34f2c/c9ra06144d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0435d1bb286d/c9ra06144d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83e/9072308/0910162a91b2/c9ra06144d-s4.jpg

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