stachybotrin C 及其全部立体异构体的合成：结构修订。

Synthesis of stachybotrin C and all of its stereoisomers: structure revision.

机构信息

Université de Rennes 1, UMR 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM, UFR des Sciences Biologiques et Pharmaceutiques, 2 avenue du Prof Léon Bernard, F-35043 Rennes Cedex, France.

出版信息

J Org Chem. 2013 Jul 19;78(14):7169-75. doi: 10.1021/jo401116r. Epub 2013 Jun 28.

DOI:10.1021/jo401116r

PMID:23772883

Abstract

We disclose the first total synthesis of stachybotrin C, a potent neuroprotective natural compound. All of the four stereoisomers have been prepared and fully characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters of the stachybotrin C.

摘要

我们首次全合成了具有强大神经保护作用的天然化合物——链格孢菌酮 C。所有四个立体异构体均已制备并进行了全面表征，旨在确定链格孢菌酮 C 中两个相邻手性中心的绝对构型。