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The induction of immunogenic cell death by type II anti-CD20 monoclonal antibodies has mechanistic differences compared with type I rituximab.

作者信息

Cheadle Eleanor J, Sidon Lauren, Dovedi Simon J, Melis Monique H M, Alduaij Waleed, Illidge Tim M, Honeychurch Jamie

出版信息

Br J Haematol. 2013 Sep;162(6):842-5. doi: 10.1111/bjh.12427. Epub 2013 Jun 18.

DOI:10.1111/bjh.12427
PMID:23772929
Abstract
摘要

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A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies.新型II型抗CD20单克隆抗体奥滨尤妥珠单抗(GA101)治疗B细胞恶性肿瘤患者的综述
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A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.一种Toll样受体7(TLR7)激动剂通过自然杀伤(NK)细胞和CD4 T细胞增强了奥滨尤妥珠单抗在小鼠淋巴瘤模型中的抗肿瘤疗效。
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