Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Eur J Neurosci. 2013 Jun;37(12):1994-2004. doi: 10.1111/ejn.12181.
The inter-relationship between vascular dysfunction and Alzheimer's disease pathology is not clearly understood; however, it is clear that the accumulation of amyloid-beta peptide and loss of vascular function contribute to the cognitive decline detected in patients. At present, imaging modalities can monitor the downstream effects of vascular dysfunction such as cerebral blood flow alterations, white and gray matter lacunes, and ischemic lesions; however, they cannot distinguish parenchymal plaques from cerebrovascular amyloid. Much of our understanding regarding the relationship between amyloid and vascular dysfunction has come from longitudinal population studies and mouse models. In this review, we will discuss the breadth of data generated on vascular function in mouse models of Alzheimer's disease and cerebrovascular amyloid angiopathy. We will also discuss therapeutic strategies targeting the reduction of cerebrovascular amyloid angiopathy and improvement of vascular function.
血管功能障碍与阿尔茨海默病病理学之间的相互关系尚不清楚；然而，很明显，β淀粉样肽的积累和血管功能的丧失导致了患者认知能力下降的检测。目前，成像方式可以监测血管功能障碍的下游影响，如脑血流改变、白质和灰质腔隙以及缺血性病变；然而，它们无法区分实质斑块和脑血管淀粉样蛋白。我们对淀粉样蛋白与血管功能障碍之间关系的了解主要来自纵向人群研究和小鼠模型。在这篇综述中，我们将讨论在阿尔茨海默病和脑血管淀粉样血管病的小鼠模型中产生的关于血管功能的广泛数据。我们还将讨论针对减少脑血管淀粉样血管病和改善血管功能的治疗策略。
