Department of Pathology, Chonnam National University Medical School, 5 Hak-dong, Dong-gu, 501-746 Gwangju, Republic of Korea.
Diagn Pathol. 2013 Jun 17;8:97. doi: 10.1186/1746-1596-8-97.
This study presents a first case of multiple peripheral typical carcinoid tumors associated with sclerosing hemangiomas in the lung. A 52-year-old male presented with incidentally detected multiple pulmonary nodules on a simple chest X-ray during routine health check-up. A computed tomography (CT) scan of the chest showed multiple nodular lesions in the middle and lower lobes of the right lung. These were initially suspected as inflammatory lesions due to miliary tuberculosis. However, possibility of malignancy could not be excluded and right lower lobe lobectomy was performed. Histopathologically, some nodules including two largest nodules were composed of small round to spindle shaped cells with fine chromatin pattern, whereas the rest of the sclerotic nodules were composed of two epithelial cell types- surface cells and round cells. The final diagnosis of this case was multiple peripheral typical carcinoid tumors associated with sclerosing hemangiomas of the lung. For past three years of post-surgery follow up period, no new lesions or changes in the right middle lobe have been identified.
本研究报告了首例肺部多发典型类癌伴硬化性血管瘤的病例。一名 52 岁男性在常规健康检查时的胸部 X 光片偶然发现多个肺部结节。胸部计算机断层扫描(CT)显示右肺中叶和下叶有多个结节性病变。由于粟粒性肺结核,最初怀疑这些病变为炎症性病变。然而,不能排除恶性病变的可能性,因此进行了右下肺叶切除术。组织病理学检查显示,一些结节,包括两个最大的结节,由具有精细染色质模式的小圆形至梭形细胞组成,而其余硬化性结节由两种上皮细胞类型-表面细胞和圆形细胞组成。该病例的最终诊断为肺部多发性典型类癌伴硬化性血管瘤。术后 3 年的随访期间,未发现新的病变或右中叶的变化。