Garraffo R, Sbirrazzuoli V, Jambou D, Lapalus P
Laboratoire de Pharmacologie, Faculté de Médecine, Nice.
Pathol Biol (Paris). 1990 Apr;38(4):261-6.
Non antibacterial effects of antibiotics are presently investigated by several authors. They estimate the effects of different molecules on polynuclear chemotaxis, cytokine production or macrophage activity. In this experiment we have studied the effects of two betalactams, two macrolides, a fluoroquinolone and a tetracycline on eicosanoïd production by stimulated human macrophages in vitro. All evaluated antibiotics are able to modify the prostaglandin and/or leukotriene production. Taking into account the immunomodulative and inflammatory properties of the eicosanoids, the variation of their production could be relevant in clinical practice.
目前，多位作者正在研究抗生素的非抗菌作用。他们评估了不同分子对多核细胞趋化性、细胞因子产生或巨噬细胞活性的影响。在本实验中，我们研究了两种β-内酰胺类抗生素、两种大环内酯类抗生素、一种氟喹诺酮类抗生素和一种四环素对体外刺激的人巨噬细胞产生类花生酸的影响。所有评估的抗生素都能够改变前列腺素和/或白三烯的产生。考虑到类花生酸的免疫调节和炎症特性，其产生的变化在临床实践中可能具有重要意义。
