[慢性淋巴细胞白血病病程中播散性水痘-带状疱疹病毒感染伴出血性胃炎：病例报告及文献复习]

[Disseminated varicella-zoster virus infection with hemorrhagic gastritis during the course of chronic lymphocytic leukemia: case report and literature review].

作者信息

Serris A, Michot J-M, Fourn E, Le Bras P, Dollat M, Hirsch G, Pallier C, Carbonnel F, Tertian G, Lambotte O

机构信息

Service de médecine interne, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France; Université Paris Sud XI, 94275 Le Kremlin-Bicêtre cedex, France.

出版信息

Rev Med Interne. 2014 May;35(5):337-40. doi: 10.1016/j.revmed.2013.05.004. Epub 2013 Jun 14.

DOI:10.1016/j.revmed.2013.05.004

PMID:23773904

Abstract

INTRODUCTION

The reactivation of varicella-zoster virus occurs in immunocompromised patients, especially in cases of hematological malignancy. Disseminated reactivation could involve digestive tract with life-threatening condition.

CASE REPORT

A 76-year-old woman, with a history of chronic lymphocytic leukemia, presented with left hypochondrium pain, and a vesicular rash with hemorrhagic shock that revealed an hemorrhagic gastritis due to varicella-zoster virus. The literature review identified 28 additional cases of gastrointestinal mucosal damage during reactivation of varicella-zoster virus. Mortality is 40%. We report here the first case in the course of low-grade lymphoid malignancy.

CONCLUSION

Acute gastrointestinal symptoms in immunocompromised patients should evoke a varicella-zoster virus reactivation with gastrointestinal involvement. This clinical manifestation, although rare, should not be ignored because of its severity.

摘要