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脂肪代谢的全身调节

Systemic regulation of adipose metabolism.

作者信息

Carmean Christopher M, Cohen Ronald N, Brady Matthew J

机构信息

The Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL 60637, USA.

The Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL 60637, USA.

出版信息

Biochim Biophys Acta. 2014 Mar;1842(3):424-30. doi: 10.1016/j.bbadis.2013.06.004. Epub 2013 Jun 14.

DOI:10.1016/j.bbadis.2013.06.004
PMID:23774083
Abstract

White adipose tissue serves as a critical energy storage depot and endocrine organ. Adipocytes are subject to numerous levels of regulation, including neuronal, endocrine and metabolic. While insulin is the classical endocrine regulator of lipid metabolism in adipose tissue, other important endocrine hormones also control adipose tissue physiology. In this review, we will focus on the contribution of the pituitary in the modulation of adipocyte function, through the direct release of growth hormone as well as via the regulation of the thyroid gland and release of thyroid hormone. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.

摘要

白色脂肪组织是一个关键的能量储存库和内分泌器官。脂肪细胞受到多种水平的调节,包括神经、内分泌和代谢调节。虽然胰岛素是脂肪组织中脂质代谢的经典内分泌调节因子,但其他重要的内分泌激素也控制着脂肪组织的生理功能。在这篇综述中,我们将重点关注垂体通过直接释放生长激素以及通过调节甲状腺和甲状腺激素释放来调节脂肪细胞功能的作用。本文是名为“健康与疾病中脂肪组织的调节”的特刊的一部分。

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