Kiss Orsolya, Tőkés Anna-Mária, Spisák Sándor, Szilágyi Anna, Lippai Norbert, Szász A Marcell, Kulka Janina
Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest.
Orv Hetil. 2013 Jun 23;154(25):963-8. doi: 10.1556/OH.2013.29643.
Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis.
The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases.
The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix® Gene Chip.
The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas.
Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.
腺样囊性癌是一种源自唾液腺的恶性肿瘤，但极少情况下也可起源于乳腺。源自唾液腺的腺样囊性癌临床预后极具侵袭性，而乳腺腺样囊性癌大多预后良好。
作者旨在比较源自乳腺和唾液腺的腺样囊性癌病例的miRNA表达谱。
使用Affymetrix®基因芯片分析了两个源自唾液腺和两个源自乳腺的腺样囊性癌组织以及一个正常乳腺组织和一个唾液腺组织的miRNA谱。
与对照相比，某些miRNA在肿瘤组织中的表达存在差异：let-7b在源自唾液腺的腺样囊性癌中过表达，而在源自乳腺的腺样囊性癌中表达降低。此外，miR-24在源自唾液腺的腺样囊性癌中表达降低，但在源自乳腺的腺样囊性癌中过表达。miR-181a-2*仅在源自唾液腺的腺样囊性癌中检测到。
通过基因的转录后调控，一些miRNA的不同表达可能部分解释了源自唾液腺和乳腺的腺样囊性癌不同的临床结局。
