移植中血管紧张素II 1型受体抗体的检测
The detection of antibodies to the Angiotensin II-type 1 receptor in transplantation.
作者信息
Dragun Duska
机构信息
Clinic for Nephrology and Intensive Care Medicine, Charité-Campus Virchow-Klinikum, Berlin, Germany.
出版信息
Methods Mol Biol. 2013;1034:331-3. doi: 10.1007/978-1-62703-493-7_19.
The detection of auto-antibodies detection is a major aspect of patient's immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney transplantation and in obliterative vasculopathy of autoimmune diseases. Here, a sandwich enzyme-linked immunosorbent assay (ELISA) is the reliable tool for the detection of auto-antibodies targeting AT1R.
自身抗体检测是患者免疫监测的一个主要方面。针对心脏和肾脏血管紧张素II 1型受体（AT1R）的抗体在心脏和肾脏移植后的抗体介导排斥反应以及自身免疫性疾病的闭塞性血管病中起主要作用。在此，夹心酶联免疫吸附测定（ELISA）是检测靶向AT1R自身抗体的可靠工具。
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