Otero L, Quintero L, Champsaur D, Simanca E
Pontificia Universidad Javeriana, Bogotá, Colombia.
Appl Clin Genet. 2010 Feb 3;3:1-6. doi: 10.2147/tacg.s8474. Print 2010.
The inheritance of class III malocclusion has been well documented, but the inheritance of craniofacial structures in Colombian families with this malocclusion has been not yet reported.
The study sample of 25 families comprised 186 untreated orthodontic individuals from 8 to 60 years old. Pedigrees were drawn using Cyrillic software. Complete family histories for each proband were ascertained and the affection status of relatives was confirmed by lateral cephalograms and facial and dental photographs. Analysis of variance and odds ratio test for each parameter was performed to estimate inheritance from parents to offspring and to determine similar phenotypic features in relatives.
The analysis of the pedigrees suggests autosomal dominant inheritance. The craniofacial characteristics that showed more resemblance between parents and offspring were middle facial height, shorter anterior cranial base and mandibular prognathism. In contrast the protrusion of upper lip and maxillary retrusion were the phenotypic features that contributed to class III in the majority of families.
Knowledge of the inheritance of craniofacial phenotypes in class III malocclusion will enable the design of new therapies to treat this malocclusion.
III类错牙合的遗传情况已有充分记录，但哥伦比亚患有此类错牙合的家庭中颅面结构的遗传情况尚未见报道。
该研究样本包括25个家庭的186名未经治疗的正畸患者，年龄在8至60岁之间。使用西里尔软件绘制系谱图。确定每个先证者的完整家族史，并通过头颅侧位片以及面部和牙齿照片确认亲属的患病情况。对每个参数进行方差分析和比值比检验，以估计从父母到后代的遗传情况，并确定亲属中相似的表型特征。
系谱分析表明为常染色体显性遗传。父母与后代之间表现出更多相似性的颅面特征是面中部高度、较短的前颅底和下颌前突。相比之下，上唇突出和上颌后缩是大多数家庭中导致III类错牙合的表型特征。
了解III类错牙合中颅面表型的遗传情况将有助于设计治疗此类错牙合的新疗法。
