牙颌面及正畸异常的遗传学
Genetics of Dentofacial and Orthodontic Abnormalities.
作者信息
Neela Praveen Kumar, Atteeri Anjana, Mamillapalli Pavan Kumar, Sesham Vasu Murthy, Keesara Sreekanth, Chandra Jaya, Monica Udayini, Mohan Vasavi
机构信息
Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, India.
Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India.
出版信息
Glob Med Genet. 2020 Dec;7(4):95-100. doi: 10.1055/s-0040-1722303. Epub 2021 Feb 1.
The development of craniofacial complex and dental structures is a complex and delicate process guided by specific genetic mechanisms. Genetic and environmental factors can influence the execution of these mechanisms and result in abnormalities. An insight into the mechanisms and genes involved in the development of orofacial and dental structures has gradually gained by pedigree analysis of families and twin studies as well as experimental studies on vertebrate models. The development of novel treatment techniques depends on in-depth knowledge of the various molecular or cellular processes and genes involved in the development of the orofacial complex. This review article focuses on the role of genes in the development of nonsyndromic orofacial, dentofacial variations, malocclusions, excluding cleft lip palate, and the advancements in the field of molecular genetics and its application to obtain better treatment outcomes.
颅面复合体和牙齿结构的发育是一个由特定遗传机制引导的复杂而精细的过程。遗传和环境因素会影响这些机制的执行并导致异常。通过对家族的系谱分析、双胞胎研究以及对脊椎动物模型的实验研究，人们逐渐深入了解了参与口面部和牙齿结构发育的机制和基因。新型治疗技术的发展依赖于对参与口面部复合体发育的各种分子或细胞过程及基因的深入了解。这篇综述文章聚焦于基因在非综合征性口面部、牙颌面变异、错牙合畸形（不包括唇腭裂）发育中的作用，以及分子遗传学领域的进展及其在获得更好治疗效果方面的应用。
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