金与铑相遇：通过 Meyer-Schuster 重排和不对称 1,4-加成串联一锅法合成β-二取代酮。
Gold meets rhodium: tandem one-pot synthesis of β-disubstituted ketones via Meyer-Schuster rearrangement and asymmetric 1,4-addition.
机构信息
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
出版信息
Org Lett. 2013 Jul 5;15(13):3226-9. doi: 10.1021/ol4011739. Epub 2013 Jun 18.
PMID:23777565
Abstract
An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched β-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is investigated.
摘要
本文报道了一种从外消旋丙炔醇出发，通过不对称一锅串联 Au/Rh 催化合成高对映选择性的 β-二取代酮的方法。研究了双金属催化体系中两种金属配合物（Au/Rh）及其正交配体体系（NHC/二烯）的相容性。
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