区域选择性转换：金（I）催化炔丙醇氧化重排为 1,3-二酮。
Regioselectivity switch: gold(I)-catalyzed oxidative rearrangement of propargyl alcohols to 1,3-diketones.
机构信息
Ruprecht-Karls-Universität Heidelberg, Organisch-Chemisches Institut, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
出版信息
J Org Chem. 2012 Sep 7;77(17):7761-7. doi: 10.1021/jo301381z. Epub 2012 Aug 21.
PMID:22877083
Abstract
The gold(I)-catalyzed oxidative rearrangement of propargyl alcohols provides an efficient and selective route to 1,3-diketones under mild conditions. Pyridine-N-oxides were used as external oxidants with, different from related substrates, no alkylidenecycloalkanones or oxetan-3-ones formed as side-products.
摘要
金（I）催化的炔丙醇的氧化重排在温和条件下为 1,3-二酮提供了一种有效和选择性的途径。吡啶-N-氧化物被用作外部氧化剂，与相关底物不同，没有形成亚烷基环烷酮或恶唑烷-3-酮作为副产物。
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