锂和铷对大鼠免疫反应的影响。

Effects of lithium and rubidium on immune responses of rats.

作者信息

Jones J M, Yeralan O, Hines G, Maher M, Roberts D W, Benson R W

机构信息

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.

出版信息

Toxicol Lett. 1990 Jul;52(2):163-8. doi: 10.1016/0378-4274(90)90150-k.

DOI:10.1016/0378-4274(90)90150-k

PMID:2378000

Abstract

Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer (NK) cells from both treated groups were significantly less than those from untreated controls. In vitro, Li augmented responses of spleen cells to LPS, but the same doses of Rb suppressed the responses. Effects on responses to Con A were variable. Both Li and Rb alone had a small mitogenic effect on spleen cells.

摘要

给大鼠饮用含LiCl或RbCl的水65天。两个处理组的脾细胞对脂多糖（LPS）的增殖反应均显著高于未处理的对照组。对伴刀豆球蛋白A（Con A）的反应未受影响。两个处理组的自然杀伤（NK）细胞的细胞毒性活性均显著低于未处理的对照组。在体外，Li增强了脾细胞对LPS的反应，但相同剂量的Rb抑制了该反应。对Con A反应的影响则各不相同。单独使用Li和Rb对脾细胞都有轻微的促有丝分裂作用。