Homo-Delarche F, Dardenne M
CNRS URA 1461, Hôpital Necker, Paris, France.
Springer Semin Immunopathol. 1993;14(3):221-38. doi: 10.1007/BF00195975.
The three different systems that contribute to development and maintenance of homeostasis, the nervous, endocrine and immune systems are closely interrelated. First, it was established that the neuroendocrine system was able to modulate the immune response. More recently, it has been shown that the immune system is able to function as a neuroendocrine organ, since it can synthesize not only hormones and neuropeptides, but also cytokines that have an impact on the neuroendocrine system. This has led to the demonstration of the existence of cytokine receptors within the nervous system. At the same time, various cytokine effects on the nervous system have been described including growth-promoting activity, neuromodulatory action, fever induction, sleep and decreased food intake. The latest element in this network of intricate interrelationships has been the demonstration of cytokine production by cells of the nervous system. Moreover, it appears that the brain is no longer the immunologically deprived site it was once thought to be, and that all phases of an immune response can potentially occur within the confines of the BBB.
对体内平衡的发展和维持起作用的三个不同系统，即神经系统、内分泌系统和免疫系统，是紧密相关的。首先，已证实神经内分泌系统能够调节免疫反应。最近，有研究表明免疫系统能够起到神经内分泌器官的作用，因为它不仅可以合成激素和神经肽，还能合成对神经内分泌系统有影响的细胞因子。这就证明了神经系统中存在细胞因子受体。与此同时，已经描述了各种细胞因子对神经系统的影响，包括促生长活性、神经调节作用、发热诱导、睡眠和食物摄入量减少。这种复杂相互关系网络中的最新元素是神经系统细胞产生细胞因子的证明。此外，大脑似乎不再是曾经被认为的免疫隔离部位，并且免疫反应的所有阶段都有可能在血脑屏障范围内发生。
