Sato S, Takizawa H, Inui N
Toxicology Research Laboratories, Japan Tobacco Inc., Kanagawa.
Toxicol Lett. 1990 Jul;52(2):215-20. doi: 10.1016/0378-4274(90)90156-g.
The frequency of micronucleated polychromatic erythrocytes (MNPCEs) was compared in BALB/c, C57BL/6 and DBA/2 mice after the intraperitoneal injection (i.p.) of methyl methanesulfonate (MMS), potassium chromate (K2CrO4), colchicine (COL), cycloheximide (CYH), 4-nitroquinoline-1-oxide (4-NQO) and 5-fluorouracil (5-FU). In BALB/c mice, the frequency of MNPCEs was significantly increased by all the chemicals tested, as compared to the vehicle control. In both C57BL/6 and DBA/2 mice, MMS, K2CrO4, COL and 4-NQO significantly increased MNPCEs, but CYH and 5-FU only slightly increased the MNPCEs in C57BL/6 and had no effect on DBA/2 mice. These results suggest that BALB/c mice are more sensitive to the induction of MNPCEs with a wider spectrum of chemicals than C57BL/6 or DBA/2 mice.
在腹腔注射甲磺酸甲酯（MMS）、铬酸钾（K2CrO4）、秋水仙碱（COL）、放线菌酮（CYH）、4-硝基喹啉-1-氧化物（4-NQO）和5-氟尿嘧啶（5-FU）后，比较了BALB/c、C57BL/6和DBA/2小鼠体内微核多染红细胞（MNPCEs）的频率。与溶剂对照组相比，在BALB/c小鼠中，所有测试化学品均显著增加了MNPCEs的频率。在C57BL/6和DBA/2小鼠中，MMS、K2CrO4、COL和4-NQO均显著增加了MNPCEs，但CYH和5-FU仅使C57BL/6小鼠的MNPCEs略有增加，而对DBA/2小鼠没有影响。这些结果表明，与C57BL/6或DBA/2小鼠相比，BALB/c小鼠对更广泛的化学品诱导MNPCEs更为敏感。
