Itoh S, Shimada H
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Mutat Res. 1996 Apr 6;367(4):233-6. doi: 10.1016/s0165-1218(96)90082-8.
The clastogenic effects of chromium compounds (CrCl3 and K2CrO4) and selenium compounds (H2SeO3 and Na2SeO4) in mouse bone marrow cells have been investigated. K2CrO4 induced significant, dose-related increases in micronuclei. H2SeO3 also showed a significant micronucleus induction at the highest dose. CrCl3 and Na2SeO4 were negative for micronuclei induction in mice. The suppressive effect of Bi(NO3)3, a metallothionein inducer, on the micronucleus induction by K2CrO4 and H2SeO3 has been also investigated. Pretreatment with Bi(NO3)3 suppressed the micronucleus induction by K2CrO4 and H2SeO3. In addition, the incidence of micronucleus induction seemed to be reduced by double dosing with K2CrO4 and H2SeO3, compared to single dosing. It is generally recognized that a number of metal compounds induce metallothionein synthesis. These results suggest that the mechanism of suppression of micronucleus induction by K2CrO4 and H2SeO3 involve possible participation of metallothionein in mouse bone marrow.
已对铬化合物（CrCl3 和 K2CrO4）和硒化合物（H2SeO3 和 Na2SeO4）对小鼠骨髓细胞的致断裂效应进行了研究。K2CrO4 诱导微核显著增加，且呈剂量相关。H2SeO3 在最高剂量时也显示出显著的微核诱导作用。CrCl3 和 Na2SeO4 对小鼠微核诱导呈阴性。还研究了金属硫蛋白诱导剂 Bi(NO3)3 对 K2CrO4 和 H2SeO3 诱导微核的抑制作用。用 Bi(NO3)3 预处理可抑制 K2CrO4 和 H2SeO3 诱导的微核。此外，与单次给药相比，K2CrO4 和 H2SeO3 联合给药似乎可降低微核诱导的发生率。人们普遍认为许多金属化合物可诱导金属硫蛋白合成。这些结果表明，K2CrO4 和 H2SeO3 抑制微核诱导的机制可能涉及金属硫蛋白在小鼠骨髓中的参与。
