直肠电位差在醛固酮增多症诊断中的应用
Rectal potential difference in the diagnosis of aldosterone excess.
作者信息
Beevers D G, Morton J J, Tree M, Young J
出版信息
Gut. 1975 Jan;16(1):36-41. doi: 10.1136/gut.16.1.36.
Abstract
Rectal potential difference (pd) is directly related to the plasma aldosterone concentration, and rises when aldosterone is stimulated by sodium deprivation. However, when the measurement of rectal pd was tested at a screening test for hyperaldosteronism in 19 hypertensive subjects, four of the eight with primary hyperaldosteronism had a normal pd and four of the eight without aldosterone excess had an abnormally raised potential difference. The technique cannot therefore be recommended as a routine screening test for hyperaldosteronism. No relationship was found between rectal pd and hypertension associated with excess of deoxycorticosterone. Rectal pd rises in response to the mineralocorticoid-like agent carbenoxolone.
摘要
直肠电位差（pd）与血浆醛固酮浓度直接相关，当因缺钠刺激醛固酮时其会升高。然而，在对19名高血压患者进行的原发性醛固酮增多症筛查试验中检测直肠pd时，8名原发性醛固酮增多症患者中有4名的pd正常，而8名无醛固酮增多的患者中有4名的电位差异常升高。因此，该技术不能作为原发性醛固酮增多症的常规筛查试验。未发现直肠pd与脱氧皮质酮过多相关的高血压之间存在关联。直肠pd会因盐皮质激素样药物甘珀酸而升高。
相似文献
1
Rectal potential difference in the diagnosis of aldosterone excess.直肠电位差在醛固酮增多症诊断中的应用
Gut. 1975 Jan;16(1):36-41. doi: 10.1136/gut.16.1.36.
2
[Rectal electrical potential difference and plasma aldosterone in hyperaldosteronism and low-, normal- and high-renin hypertension].[原发性醛固酮增多症及低肾素、正常肾素和高肾素型高血压患者的直肠电位差与血浆醛固酮]
Wien Klin Wochenschr. 1976 Dec 10;88(23):777-81.
3
Inter-relationships between plasma angiotensin II, arterial pressure, aldosterone and exchangeable sodium in normotensive and hypertensive man.
J Steroid Biochem. 1975 May;6(5):779-84. doi: 10.1016/0022-4731(75)90067-9.
4
Plasma renin activity and aldosterone secretion in hypertensive patients during high and low sodium intake and administration of diuretic.
J Clin Endocrinol Metab. 1968 Mar;28(3):359-71. doi: 10.1210/jcem-28-3-359.
5
Subtraction potential difference: In-vivo assay for mineralocorticoid activity.
Lancet. 1978 Feb 11;1(8059):298-302. doi: 10.1016/s0140-6736(78)90070-3.
6
[Renin-angiotensin-(aldosterone)-system-clinical aspects].
Z Gesamte Inn Med. 1973 Dec 15;28(24):757-62.
7
Response of plasma aldosterone to fludrocortisone in primary hyperaldosteronism and other forms of hypertension.
Clin Endocrinol (Oxf). 1975 Sep;4(5):493-500. doi: 10.1111/j.1365-2265.1975.tb01559.x.
8
Body-sodium and blood volume in a patient with licorice-induced hypertension.一名患有甘草诱导性高血压患者的体内钠含量和血容量
J Hypertens. 1985 Feb;3(1):19-23. doi: 10.1097/00004872-198502000-00004.
9
10
Measurement of rectal electrical potential difference as an instant screening-test for hyperaldosteronism.
Lancet. 1970 Sep 26;2(7674):624-7. doi: 10.1016/s0140-6736(70)91397-8.
引用本文的文献
1
Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy.醛固酮在妇科中的作用及其与妊娠高血压风险的关系。
Front Endocrinol (Lausanne). 2019 Aug 23;10:575. doi: 10.3389/fendo.2019.00575. eCollection 2019.
2
The effect of cathartic agents on transmucosal electrical potential difference in the human rectum.泻药对人体直肠跨黏膜电位差的影响。
Klin Wochenschr. 1980 Mar 17;58(6):299-306. doi: 10.1007/BF01476572.
3
Hormonal regulation of electrolyte and water transport in the colon.结肠中电解质和水转运的激素调节。
Klin Wochenschr. 1984 Jun 15;62(12):555-63. doi: 10.1007/BF01728173.
4
Adrenal aldosterone-producing adenoma: use of colonic potential in diagnosis and subtraction scanning technique for localisation.
Br Med J. 1976 Jul 3;2(6026):11-4. doi: 10.1136/bmj.2.6026.11.
5
Spironolactone in essential hypertension: evidence against its effect through mineralocorticoid antagonism.螺内酯治疗原发性高血压：反对其通过盐皮质激素拮抗作用发挥疗效的证据。
Br Med J. 1976 Mar 20;1(6011):682-4. doi: 10.1136/bmj.1.6011.682.
6
A comparison of some extra-renal effects of spironolactone and canrenone.螺内酯和坎利酮的一些肾外效应比较。
Br J Clin Pharmacol. 1979 Apr;7(4):385-92. doi: 10.1111/j.1365-2125.1979.tb00950.x.
7
Aldosterone and in vivo mineralocorticoid activity in normotensive and hypertensive man.正常血压和高血压男性体内的醛固酮及盐皮质激素活性
J R Soc Med. 1979 Apr;72(4):252-9. doi: 10.1177/014107687907200404.
本文引用的文献
1
NORMOKALEMIC PRIMARY ALDOSTERONISM. A DETECTABLE CAUSE OF CURABLE "ESSENTIAL" HYPERTENSION.正常血钾性原发性醛固酮增多症。可治愈的“原发性”高血压的一个可检测病因。
JAMA. 1965 Jul 19;193:200-6. doi: 10.1001/jama.1965.03090030022005.
2
3
EFFECT OF D-ALDOSTERONE ON SALT AND WATER ABSORPTION FROM THE INTACT HUMAN COLON.D-醛固酮对完整人结肠盐和水吸收的影响
J Clin Invest. 1965 May;44(5):801-8. doi: 10.1172/JCI105192.
4
D-ALDOSTERONE AND SWEAT ELECTROLYTES.
J Appl Physiol. 1964 Jul;19:575-9. doi: 10.1152/jappl.1964.19.4.575.
5
Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome.主席致辞。一、绘画背景。二、原发性醛固酮增多症，一种新的临床综合征。
J Lab Clin Med. 1955 Jan;45(1):3-17.
6
Changes in salivary electrolytes following treatment of primary aldosteronism.原发性醛固酮增多症治疗后唾液电解质的变化。
Arch Intern Med. 1969 Oct;124(4):477-80.
7
The effect of adrenal steroids on stool composition, as revealed by in vivo dialysis of faeces.
Clin Sci. 1969 Aug;37(1):151-67.
8
The meaning of aldosteronism in hypertensive disease.
Circ Res. 1967 Jul;21(1):Suppl 2:177+.
9
A simple millivoltmeter and electrodes for measurement of rectal electrical potential in man.
Med Biol Eng. 1970 Jul;8(4):409-10. doi: 10.1007/BF02477670.
10
A preliminary evaluation for primary aldosteronism.原发性醛固酮增多症的初步评估。
Arch Intern Med. 1970 Dec;126(6):1004-7.
Zotero 插件