Babizhaev M A, Brodskaia M V, Batmanov Iu E
Vestn Oftalmol. 1990 Jan-Feb;106(1):51-6.
The content of fibronectin, an extracellular glycoprotein, in the drainage out-flow system of human eyes was measured by the indirect immunoperoxidase staining technique. The degree of fibronectin accumulation in ocular tissues was evaluated by quantitative morphometric analysis. Fibronectin level in the ocular drainage system of humans grows with ageing and rapidly increases at different stages of primary open-angle glaucoma development. Increased deposit of fibronectin in trabecular tissue, mainly in the inner wall of Schlemm's canal and juxtacanalicular or cribriform part of trabecular meshwork, was demonstrated. A hypothesis explaining the development of the glaucomatous process by an adhesive impairment is proposed.
采用间接免疫过氧化物酶染色技术测定了人眼引流系统中细胞外糖蛋白纤连蛋白的含量。通过定量形态计量分析评估了眼组织中纤连蛋白的积累程度。人类眼引流系统中的纤连蛋白水平随年龄增长而升高，并在原发性开角型青光眼发展的不同阶段迅速增加。结果表明，小梁组织中纤连蛋白沉积增加，主要在施莱姆管内壁以及小梁网的邻管区或筛状部分。提出了一种通过黏附功能受损来解释青光眼发病过程的假说。
