Babizhayev M A, Brodskaya M W
Moscow Helmholtz Research Institute of Eye Diseases, U.S.S.R.
Mech Ageing Dev. 1989 Feb;47(2):145-57. doi: 10.1016/0047-6374(89)90017-1.
The content of the fibronectin, an extracellular glycoprotein in the drainage outflow system of human eyes was determined by the indirect immunoperoxidase staining technique. The degree of fibronectin accumulation in ocular tissues was evaluated by quantitative morphometric analysis. It was shown that the fibronectin level was elevated in the ocular drainage outflow system of humans in ageing and was rapidly increased at different stages of primary open-angle glaucoma development. Increased deposit of fibronectin in trabecular tissues, mainly, in the inner wall of Schlemm's canal and juxtacanalicular, or cribriform part of trabecular meshwork, was demonstrated along with ageing and glaucoma disease progression. A hypothesis underlying the glaucomatous process as an adhesive impairment was proposed.
采用间接免疫过氧化物酶染色技术测定了人眼引流系统中细胞外糖蛋白纤连蛋白的含量。通过定量形态计量分析评估了纤连蛋白在眼组织中的积累程度。结果表明，随着年龄增长，人眼引流系统中的纤连蛋白水平升高，并且在原发性开角型青光眼发展的不同阶段迅速增加。随着年龄增长和青光眼病情进展，小梁组织中，主要是施莱姆管内壁和小梁网近管区或筛状部分的纤连蛋白沉积增加。提出了一种将青光眼过程视为黏附功能障碍的假说。
