Musiol Katarzyna, Sobol Grazyna, Mizia-Malarz Agnieszka, Wos Halina
Department of Pediatric Oncology, Hematology, and Chemotherapy, Upper Silesia Children's Care Health Centre, Medical University of Silesia, 16 Medykow Str., 40-752, Katowice, Poland,
Childs Nerv Syst. 2014 Jan;30(1):131-6. doi: 10.1007/s00381-013-2183-8. Epub 2013 Jun 19.
To assess the nutritional status in children with central nervous system (CNS) tumours, including concentration of leptin, the neuropeptide responsible for regulation of energetic homeostasis in an organism.
The studied group comprised 44 children with brain tumours, aged (4.02-18.7). In all children during the whole therapy (from the start to the period of 1 year and more after the end of therapy), a number of standard deviations (SDs) for the body mass index (SDS BMI) was derived from anthropometric measurements. Concentrations of leptin were assayed simultaneously.
The lowest values of the anthropometric indices were found in children during the maintenance therapy. Concentrations of leptin in patients with malignant CNS tumours and significant undernutrition were slightly greater as compared to patients presenting normal nutritional status; however, without statistical significance.
In children with tumours of the central nervous system, there are quantitative disorders of the nutritional status which correlate with the period of the treatment. The most significant disorders in the nutritional status are observed during maintenance chemotherapy. There was no statistically significant correlation between the concentration of leptin and nutritional status in children with malignant brain tumours during the course of treatment and after its completion.
评估中枢神经系统（CNS）肿瘤患儿的营养状况，包括瘦素（负责调节机体能量平衡的神经肽）的浓度。
研究组包括44例脑肿瘤患儿，年龄在（4.02 - 18.7）岁之间。在所有患儿整个治疗期间（从开始治疗到治疗结束后1年及更长时间），通过人体测量得出体重指数的标准差数量（SDS BMI）。同时检测瘦素浓度。
维持治疗期间患儿的人体测量指标值最低。恶性CNS肿瘤且严重营养不良的患者瘦素浓度与营养状况正常的患者相比略高，但无统计学意义。
中枢神经系统肿瘤患儿存在营养状况的定量紊乱，且与治疗阶段相关。维持化疗期间营养状况紊乱最为显著。在治疗过程中及治疗结束后，恶性脑肿瘤患儿的瘦素浓度与营养状况之间无统计学显著相关性。
