通过三苯基膦催化的[3+2]环加成反应立体选择性合成官能化螺环戊烯氧吲哚。
Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions.
机构信息
School of Basic Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
出版信息
Mol Divers. 2013 Aug;17(3):563-71. doi: 10.1007/s11030-013-9456-8. Epub 2013 Jun 19.
PMID:23780558
Abstract
Spirocyclopenteneoxindole derivatives were obtained by stereoselective triphenylphosphine-catalyzed [3+2] cycloadditions of ynones and alkylidene oxindole derivatives. This approach is based on the Michael addition of ynones to alkylidene oxindole derivatives, followed by intermolecular [Formula: see text]-addition using 50 mol% triphenylphosphine as catalyst.
摘要
螺环戊烯并吲哚衍生物通过立体选择性三苯基膦催化的炔酮和亚甲基氧化吲哚衍生物的[3+2]环加成反应得到。这种方法基于炔酮与亚甲基氧化吲哚衍生物的迈克尔加成，然后使用 50mol%三苯基膦作为催化剂进行分子间[Formula: see text]-加成。
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