Institute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain.
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7818-21. doi: 10.1002/anie.201302372. Epub 2013 Jun 18.
The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on palladium-catalyzed cross-couplings permitted a modular construction of this natural product.
噻肽类抗生素巴龙霉素已被合成,其结构和立体化学已被证实。该天然产物采用基于钯催化交叉偶联的策略进行模块化构建。