Service of Neurology, University Hospital "Marqués de Valdecilla" (IFIMAV), University of Cantabria and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas" (CIBERNED), Av Valdecilla s/n, 39008, Santander, Spain,
Neurol Sci. 2013 Oct;34(10):1879-81. doi: 10.1007/s10072-013-1475-9. Epub 2013 Jun 19.
Herpes simplex encephalitis (HSE) is the most important viral encephalitis due to its high mortality and neurological sequelae. The aim of this study was to contribute to better characterise the HSE. We retrospectively analysed patients with a diagnosis of HSE in our hospital during 2000 and 2010. We included those patients who had a positive result for PCR for herpes simplex virus in cerebrospinal fluid and those with a negative result presenting with a consistent clinical and neuroimage profile. We included 26 patients (10 men, 16 women). Mean age was 58 years. Most frequent symptoms at admission were fever, confusion, aphasia and seizures. Mortality rate was 11 %. 2 patients presented a clinical relapse. In conclusion, the most frequent neurological sequelae were aphasia and amnesia. Disorientation, hyponatremia and abnormalities in initial brain CT were identified as new prognostic factors.
单纯疱疹病毒性脑炎（HSE）是最重要的病毒性脑炎，因其高死亡率和神经后遗症而备受关注。本研究旨在更好地描述 HSE 的特征。我们回顾性分析了 2000 年至 2010 年期间我院诊断为 HSE 的患者。我们纳入了脑脊液单纯疱疹病毒 PCR 阳性且临床表现和神经影像学一致但 PCR 结果阴性的患者。共纳入 26 例患者（男 10 例，女 16 例）。平均年龄为 58 岁。入院时最常见的症状是发热、意识模糊、失语和癫痫发作。死亡率为 11%。2 例患者出现临床复发。结论：最常见的神经后遗症是失语和遗忘。定向障碍、低钠血症和初始脑 CT 异常被确定为新的预后因素。
