Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California.
Head Neck. 2014 Feb;36(2):203-8. doi: 10.1002/hed.23278. Epub 2013 Jun 18.
The purpose of this study was to explore the risk of developing of sudden sensorineural hearing loss (SSHL) in patients with nasopharyngeal carcinoma (NPC).
A population-based, retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted. From 2001 to 2006, 9121 patients with newly diagnosed NPC and 45,605 comparison subjects without NPC were selected. The incidence of SSHL at the end of 2009 was determined.
The incidence of SSHL was 6.53-fold higher in the NPC group compared to the non-NPC group (p < .001). Using Cox proportional hazard regressions, the risk of developing SSHL increased with an adjusted hazard ratio (HR) of 6.747 (95% confidence interval [CI] = 5.366-8.484) in patients with NPC compared with patients without NPC.
NPC was significantly associated with an increased risk of developing SSHL. The risk of developing SSHL increased over follow-up time.
本研究旨在探讨鼻咽癌（NPC）患者发生突发性聋（SSHL）的风险。
采用基于人群的回顾性队列研究，使用台湾全民健康保险研究数据库。2001 年至 2006 年，选择了 9121 例新诊断的 NPC 患者和 45605 例无 NPC 的对照患者。2009 年底确定 SSHL 的发生率。
NPC 组的 SSHL 发生率是无 NPC 组的 6.53 倍（p <.001）。使用 Cox 比例风险回归，与无 NPC 患者相比，NPC 患者发生 SSHL 的风险增加，调整后的风险比（HR）为 6.747（95%置信区间[CI] = 5.366-8.484）。
NPC 与 SSHL 发生风险增加显著相关。随着随访时间的延长，发生 SSHL 的风险增加。
