Department of Otolaryngology Head Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2020 Sep;83(9):865-869. doi: 10.1097/JCMA.0000000000000314.
The aim of this study was to compare the risk of developing sudden sensorineural hearing loss (SSHL) in patients with hypopharyngeal cancer with that in patients with nasopharyngeal carcinoma (NPC).
A population-based, retrospective cohort study was performed using the Taiwan National Health Research Database databank. Patients selected for this study were diagnosed with hypopharyngeal cancer or NPC and treated with radiotherapy in the period from 2001 to 2004. Routine follow-up was conducted for 8 years (2004-2012), and the incidence of SSHL was calculated at the final follow-up.
There was no significant difference in the risk of developing SSHL between the hypopharyngeal cancer group and its control group (p = 1.000). In hypopharyngeal cancer and NPC groups, the rates of SSHL were 0.12% and 1.00%, respectively (p < 0.001). The cumulative hazard of SSHL during the follow-up period was significantly higher in the NPC group than in the control group (p < 0.001).
Radiotherapy in patients with hypopharyngeal cancer did not increase the risk of developing SSHL, but postirradiation NPC was significantly associated with an increased incidence of SSHL.
本研究旨在比较下咽癌患者与鼻咽癌（NPC）患者发生突发性感觉神经性听力损失（SSHL）的风险。
采用基于人群的回顾性队列研究，使用台湾国家健康研究数据库数据库。本研究选取的患者被诊断为下咽癌或 NPC，并在 2001 年至 2004 年期间接受放射治疗。对患者进行了 8 年的常规随访（2004 年至 2012 年），并在最后一次随访时计算 SSHL 的发病率。
下咽癌组与对照组之间发生 SSHL 的风险无显著差异（p = 1.000）。在下咽癌和 NPC 组中，SSHL 的发生率分别为 0.12%和 1.00%（p < 0.001）。在随访期间，NPC 组的 SSHL 累积发生率明显高于对照组（p < 0.001）。
放射治疗下咽癌患者不会增加 SSHL 的发病风险，但 NPC 与放疗后 SSHL 的发病率升高显著相关。
