[儿童神经母细胞瘤的免疫细胞表型与预后]
[The immunological cellular phenotype and the prognosis in neuroblastoma in children].
作者信息
Novikov A M, Blinov V M, Bukhny A F, Bassalyk L S
出版信息
Vopr Onkol. 1990;36(6):693-7.
Ganglioside profile was evaluated in 19 samples of tumor tissue obtained from 13 surgical patients with various morphological patterns of neuroblastoma. In six of those cases, two samples from each proving most different in terms of cell maturity were selected for examination. The relative content of GD2 gangliosides was 27.0-37.6% in sympathoblastoma and as low as 5.1-14.8% in ganglioneuroblastoma. Ganglioneuroblastomas showed fairly high levels of GM1 and GD1a gangliosides which were almost completely absent in sympathoblastomas. Ganglioside profile variations seen within each tumor type were incomparable with differences in profile established between morphological patterns of neuroblastoma studied.
对13例手术患者的19份肿瘤组织样本进行了神经节苷脂分析，这些患者患有不同形态学类型的神经母细胞瘤。在其中6例中，从细胞成熟度差异最大的每个病例中选取两个样本进行检测。GD2神经节苷脂在成神经细胞瘤中的相对含量为27.0%-37.6%，而在神经节神经母细胞瘤中低至5.1%-14.8%。神经节神经母细胞瘤显示出相当高水平的GM1和GD1a神经节苷脂，而成神经细胞瘤中几乎完全没有。在每种肿瘤类型中观察到的神经节苷脂谱变化与所研究的神经母细胞瘤形态学类型之间所确定的谱差异无法相比。
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