Zabel M, Lindscheid K R, Mark H
Knappschafts-Krankenhaus Recklinghausen, Abteilung für Dermatologie und Allergologie.
Z Hautkr. 1990 May;65(5):481-2, 485-6.
Sensitization due to copper has rarely been reported, so far. There is no standard patch test regarding allergy against copper sulphate (CSA). Our study is concerned with the evaluation of data of 10.936 patients patch tested between 1975 and 1985. Since--aside from external exposure--internal exposure to copper sulphate has become increasingly significant, we additionally tested 118 female patients who were or had been wearing intrauterine contraceptives containing copper. Our results showed that CSA is relatively rare and not as often found as sensitization to cobalt or nickel. CSA is rarely monovalent, but usually associated with other metal allergies, especially with nickel and cobalt sensitization. Since we frequently saw toxic reactions to copper sulphate, the skin tests should be performed with 0.5 or 0.01% copper sulphate in water. The test persons with intrauterine contraceptives were not often sensitive either; thus the likelihood of CSA seems to be small in these cases. Individual patients, however, may develop skin eruptions caused by an intrauterine contraceptive containing copper sulphate, as we can prove in one of our patients.
到目前为止，因铜致敏的情况鲜有报道。目前尚无针对硫酸铜过敏（CSA）的标准斑贴试验。我们的研究旨在评估1975年至1985年间接受斑贴试验的10936例患者的数据。由于除了外部接触外，硫酸铜的内部接触也变得越来越重要，我们还对118名正在或曾经使用含铜宫内节育器的女性患者进行了测试。我们的结果表明，CSA相对罕见，不像对钴或镍致敏那样常见。CSA很少是单一的，通常与其他金属过敏有关，尤其是镍和钴致敏。由于我们经常看到对硫酸铜的毒性反应，皮肤试验应以0.5%或0.01%的硫酸铜水溶液进行。使用宫内节育器的受试对象也不常出现过敏；因此，在这些情况下发生CSA的可能性似乎很小。然而，正如我们在一名患者身上所证实的，个别患者可能会因含硫酸铜的宫内节育器而出现皮肤疹。
