Hausen B M, Hohlbaum W
Dtsch Med Wochenschr. 1986 Jun 27;111(26):1016-21. doi: 10.1055/s-2008-1068575.
Allergological examinations were conducted on 49 women (out of a gynaecological clientele of 982) with different degrees of complaints after wearing an intrauterine device (IUD). At the same time, they and a control group had an histological examination of endometrial biopsies. Nickel allergy was found in 38 of the 49. Nine of them (eight with a nickel sensitivity) reacted within 24 hours to an application of a 1% copper sulphate solution. A reaction was still present 72 hours later in six women. Only one woman still reacted to further dilution of the test solution, but 48-hour application of the copper spiral to her forearm was negative. It is only in this patient that a (though very weak) copper allergy can be accepted with certainty. There was no evidence of an endometrial allergy histologically. The results justify the view that copper allergy is extremely rare.
对49名（在982名妇科患者中）佩戴宫内节育器（IUD）后出现不同程度不适的女性进行了变应性检查。与此同时，她们和一个对照组进行了子宫内膜活检的组织学检查。49人中发现38人对镍过敏。其中9人（8人对镍敏感）在涂抹1%硫酸铜溶液后24小时内出现反应。72小时后，6名女性仍有反应。只有一名女性对测试溶液的进一步稀释仍有反应，但将铜螺旋在前臂上放置48小时对她来说呈阴性。只有在这名患者中，可以确定存在（尽管非常轻微的）铜过敏。组织学上没有子宫内膜过敏的证据。这些结果证明了铜过敏极其罕见这一观点。
