Prasad Kedar N, Bondy Stephen C
Antioxidant Research Institute, Premier Micronutrient Corporation, 14 Galli Drive, Suite 200, Novato CA 94949, USA.
Curr Aging Sci. 2013 Dec;6(3):215-9. doi: 10.2174/18746098112059990031.
Recently the relationship between oxidative stress and aging has been brought into question. It has been suggested that while oxidative events may play a role in the progression of age-related pathologies, it is not relevant to aging processes not involving specific diseases associated with senescence. The evidence in support of this concept is largely based on studies with the roundworm, Caenorhabditis elegans (C. elegans) that has been extensively used as a model system to study aging. This commentary evaluates data derived from C. elegans and documents that the preponderance of evidence from this species supports the role of pro-oxidant events as being a significant contributor to normal aging. Possible reasons for some anomalous findings conflicting with this concept, are discussed.
最近，氧化应激与衰老之间的关系受到了质疑。有人提出，虽然氧化事件可能在与年龄相关的病理过程中起作用，但与不涉及与衰老相关的特定疾病的衰老过程无关。支持这一概念的证据主要基于对蛔虫秀丽隐杆线虫（C. elegans）的研究，该线虫已被广泛用作研究衰老的模型系统。本评论评估了来自秀丽隐杆线虫的数据，并记录了来自该物种的大量证据支持促氧化事件在正常衰老中起重要作用。文中还讨论了一些与这一概念相矛盾的异常发现的可能原因。
