Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea.
Immunol Invest. 2013;42(6):481-92. doi: 10.3109/08820139.2013.789910. Epub 2013 Jun 19.
The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and monocyte chemoattractant protein-1 (MCP-1) polymorphisms confer susceptibility to systemic sclerosis (SSc).
MEDLINE and manual search were utilized to identify available articles. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, -1661 A/G, and -1722 C/T, and MCP-1 -2518 A/G polymorphisms, using a fixed-effect or random-effect model based on between-study heterogeneity.
Eleven comparative studies involving 959 SSc patients and 1739 controls were included in the meta-analysis. No association was found between SSc and the CTLA-4 +49 A/G polymorphism (OR for the +49 G allele = 1.032, 95% CI = 0.830-1.283, p = 0.779). However, an association between SSc and the CTLA-4 -318 TT + TC genotype (OR = 1.642, 95% CI = 1.034-2.609, p = 0.036). Meta-analyses failed to reveal an association between SSc and CTLA-4 -1722 C/T, MCP-1 -2518 A/G polymorphisms.
This meta-analysis of published data shows that the CTLA-4 -318 C/T polymorphism confers susceptibility to SSc.
本研究旨在探讨细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）和单核细胞趋化蛋白 1（MCP-1）多态性是否与系统性硬化症（SSc）易感性相关。
采用 MEDLINE 和手工检索，以确定可用的文章。采用固定效应或随机效应模型，根据研究间异质性，对 CTLA-4 +49 A/G、-318 C/T、-1661 A/G 和 -1722 C/T 以及 MCP-1 -2518 A/G 多态性与 SSc 之间的关联进行荟萃分析。
纳入了 11 项包含 959 例 SSc 患者和 1739 例对照的对比研究。SSc 与 CTLA-4 +49 A/G 多态性之间无关联（+49 G 等位基因的 OR=1.032，95%CI=0.830-1.283，p=0.779）。然而，CTLA-4 -318 TT+TC 基因型与 SSc 之间存在关联（OR=1.642，95%CI=1.034-2.609，p=0.036）。荟萃分析未能显示 SSc 与 CTLA-4 -1722 C/T、MCP-1 -2518 A/G 多态性之间存在关联。
本荟萃分析表明 CTLA-4 -318 C/T 多态性与 SSc 易感性相关。
