Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, South Korea.
Mol Biol Rep. 2013 Apr;40(4):2985-93. doi: 10.1007/s11033-012-2370-9. Epub 2012 Dec 24.
The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G, CT60 A/G, and protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T polymorphisms confer susceptibility to vitiligo. A meta-analysis was conducted of the associations between the CTLA-4 +49 A/G, CT60 and PTPN22 1858 C/T polymorphisms and vitiligo using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 14 separate comparisons were considered in our meta-analysis consisting of 3,404 patients with vitiligo and 5,069 controls (nine studies with 1,252 cases and 2,152 controls for the CTLA-4 polymorphisms and five studies with 1,800 cases and 3,269 controls for the PTPN22 polymorphism). Meta-analysis showed no association between vitiligo and the CTLA-4 +49 A/G polymorphism in all study subjects (OR of the G allele = 1.186, 95 % CI = 0.893-1.575, p = 0.240) and in European (OR = 1.016, 95 % CI = 0.873-1.182, p = 0.838). However, meta-analysis of the CTLA-4 CT60 A/G polymorphism showed an association between vitiligo and the CTLA-4 CT60 G allele in all study subjects (OR = 1.267, 95 % CI = 1.110-1.447, p = 4.5 × 10(-5)) and in the European group (OR = 1.345, 95 % CI = 1.163-1.556, p = 6.3 × 10(-6)). Analysis using the recessive model and homozygote contrast showed the same pattern for the CTLA-4 CT60 G allele. Meta-analysis of the PTPN22 1858 C/T polymorphism showed an association between the PTPN22 T allele and vitiligo in all subjects (OR = 1.507, 95 % CI = 1.320-1.720, p < 1.0 × 10(-8)) and in European group (OR = 1.530, 95 % CI = 1.339-1.748, p < 1.0 × 10(-8)), but not in Asians (OR = 0.482, 95 % CI = 0.152-1.530, p = 0.216). Analysis using the recessive, dominant model, and homozygote contrast showed the same pattern for the PTPN22 T allele. This meta-analysis demonstrates that the CTLA-4 CT60 A/G polymorphism confers susceptibility to vitiligo in Europeans, but no association was found between the CTLA-4 +49 A/G polymorphism and vitiligo susceptibility. The PTPN22 C1858T polymorphism is associated with vitiligo susceptibility in European population.
本研究旨在探讨细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）+49A/G、CT60A/G 和蛋白酪氨酸磷酸酶非受体 22（PTPN22）1858C/T 多态性是否与白癜风易感性相关。采用等位基因对比、隐性模型、显性模型和加性模型对 CTLA-4+49A/G、CT60 和 PTPN221858C/T 多态性与白癜风的相关性进行了荟萃分析；共纳入了 14 项独立研究，包括 3404 例白癜风患者和 5069 例对照（9 项研究中 1252 例白癜风患者和 2152 例对照用于 CTLA-4 多态性分析，5 项研究中 1800 例白癜风患者和 3269 例对照用于 PTPN22 多态性分析）。荟萃分析显示，在所有研究对象中，CTLA-4+49A/G 多态性与白癜风均无相关性（G 等位基因的 OR = 1.186，95%CI = 0.893-1.575，p = 0.240），且在欧洲人群中也无相关性（OR = 1.016，95%CI = 0.873-1.182，p = 0.838）。然而，CTLA-4 CT60A/G 多态性的荟萃分析显示，在所有研究对象和欧洲人群中，CTLA-4 CT60G 等位基因与白癜风相关（OR = 1.267，95%CI = 1.110-1.447，p = 4.5×10(-5)）和（OR = 1.345，95%CI = 1.163-1.556，p = 6.3×10(-6)）。采用隐性模型和纯合子对比分析，CTLA-4 CT60G 等位基因也呈现出相同的模式。PTPN221858C/T 多态性的荟萃分析显示，在所有研究对象和欧洲人群中，PTPN22T 等位基因与白癜风相关（OR = 1.507，95%CI = 1.320-1.720，p < 1.0×10(-8)）和（OR = 1.530，95%CI = 1.339-1.748，p < 1.0×10(-8)），但在亚洲人群中无相关性（OR = 0.482，95%CI = 0.152-1.530，p = 0.216）。采用隐性、显性模型和纯合子对比分析，PTPN22T 等位基因也呈现出相同的模式。本荟萃分析表明，CTLA-4 CT60A/G 多态性与欧洲人群的白癜风易感性相关，但 CTLA-4+49A/G 多态性与白癜风易感性无关。PTPN22C1858T 多态性与欧洲人群的白癜风易感性相关。
