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恩诺沙星对猪源沙门氏菌的药敏折点

Susceptibility breakpoint for enrofloxacin against swine Salmonella spp.

机构信息

National Reference Laboratory of Veterinary Drug Residues/MOA Key Laboratory of the Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

出版信息

J Clin Microbiol. 2013 Sep;51(9):3070-2. doi: 10.1128/JCM.01096-13. Epub 2013 Jun 19.

DOI:10.1128/JCM.01096-13
PMID:23784134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3754624/
Abstract

Susceptibility breakpoints are crucial for prudent use of antimicrobials. This study has developed the first susceptibility breakpoint (MIC ≤ 0.25 μg/ml) for enrofloxacin against swine Salmonella spp. based on wild-type cutoff (COWT) and pharmacokinetic-pharmacodynamic (PK-PD) cutoff (COPD) values, consequently providing a criterion for susceptibility testing and clinical usage of enrofloxacin.

摘要

药敏折点对于谨慎使用抗菌药物至关重要。本研究基于野生型折点（COWT）和药代动力学-药效学（PK-PD）折点（COPD）值，制定了恩诺沙星对猪源沙门氏菌的第一个药敏折点（MIC≤0.25μg/ml），为恩诺沙星的药敏检测和临床应用提供了依据。

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